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Nephrology

Nephrology

Patients with chronic renal failure are exposed to increased morbidity and mortality as a result of cardiovascular events. Therefore, prevention and treatment of cardiovascular disease is a major goal in the management of these patients. At the same time, vascular injury can also be a causal factor in renal disease, particularly in diabetic nephropathy and […]

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Endocrinology

Endocrinology

The first objective of this research line is to investigate the underlying regulatory mechanisms involved in disturbances of glucose and lipid metabolism and their complications, including atherosclerosis, steatosis, and obesity. The results of these clinical and experimental studies are important for the development of new targets for the treatment of type 2 diabetes mellitus and […]

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Islet group

Islet group

Research in the Islet group concentrates on islet cell identity, islet survival and function, and strategies in order to improve and expand beta-cell replacement therapy. The group started in 2006 when a human islet isolation laboratory was established in the LUMC followed by a clinical islet transplantation program in 2007. This enabled the focus on […]

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Thrombosis and Hemostasis

The blood coagulation system consists of an intricate set of reactions that protect the body from bleeding and thrombosis. In general, the system is well-balanced and excessive bleeding or runaway coagulation in an individual are not daily events, but the life-time risk of a single event is nevertheless high. In cases with profound inherited or […]

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Clinical Epidemiology

Clinical Epidemiology

Clinical epidemiology consists of the application of general epidemiologic principles in clinical research. The department has two aims: to apply these principles to particular research questions, and to study the methods themselves. Generally, the research concerns questions which necessitate a numerical approach, and in which the patient is the unit of observation. Specifically, the programme […]

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Vascular Surgery

Vascular Surgery

Research within the Department of Vascular Surgery has a strong emphasis on translational research (close cooperation and integration of basic and clinical research). Research is essentially focused on (a) the (pathological) arterial vessel wall of peripheral arteries and (b) compromised organ perfusion and its consequences (ischemic damage and necrosis). Current main research topics are pathogenesis […]

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Cardiology

Cardiology

This programme encompasses basic, clinical (both diagnostic and therapeutic) and genetic research in the field of coronary atherosclerosis, in particular lipid metabolism, vascular biology, molecular plaque imaging, and novel therapeutic interventions. To this purpose, the collaboration in the working group Leiden Vascular Medicine (LVM) and Center for Medical Systems Biology (SMSB) aims to apply innovative […]

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