The first objective of this research line is to investigate the underlying regulatory mechanisms involved in disturbances of glucose and lipid metabolism and their complications, including atherosclerosis, steatosis, and obesity. The results of these clinical and experimental studies are important for the development of new targets for the treatment of type 2 diabetes mellitus and atherosclerosis. Specifically, we evaluate the roles of the central nervous system, the gut-brain axis, and of tissue specific lipid metabolism in the modulation of insulin sensitivity of glucose metabolism.