Neuroimmune guidance cues, MicroRNAs & Inflammatory responses: Sex differences in CardioVascular Diseases

Cardiovascular disease remains number one cause of premature death in women. Despite advances in the diagnosis, prevention and treatment of cardiovascular disease, the risk of coronary artery disease in women increases dramatically after menopause. In this MISs-CVD project we aim to better understand sex-specific biology in the vessel wall. Specifically, sex-biased non-coding microRNAs that can regulate proteins that ‘guide’ white blood cells playing a role in the development of arteriosclerosis. This will provide crucial understanding of the gender differences in atherosclerosis and may deliver gender specific therapeutic avenues to combat atherogenesis in both men and women.

We facilitate a limited number of internships for undergraduate students. If you’re interested, please contact Janine van Gils (j.m.van_gils@lumc.nl) to discuss the possibilities.