Eva Viho

Glucocorticoid stress hormones can influence both brain function and metabolic health via the glucocorticoid receptor (GR). GR has a transcriptional activity which is highly context-specific and differs between tissues and even between cell types. The outcome of GR-mediated transcription depends on the interactome of associated coregulators and chromatin remodelers. Selective Glucocorticoid Receptor Modulators (SGRMs) are a class of GR ligands that can be used to activate only a subset of GR interactions, thereby giving the possibility to induce a unique combination of agonistic and antagonistic GR properties. Beyond their therapeutic value, SGRMs can be used as molecular filters to characterize context-specific GR interactome and transcriptional activity that are responsible for particular glucocorticoid-driven effects. I investigate SGRMs in cognitive processes such as memory consolidation, neurodevelopmental disorders, metabolic syndrome and liver steatosis. The ultimate objective is to identify molecular processes that are responsible for adaptive and maladaptive effects of glucocorticoids.

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