Cyriel Olie

During his Master’s degree at Leiden University, he conducted a collaborative research project in 2016 between the Leiden University Medical Center (LUMC) and the University of Oxford. This collaboration sparked a strong interest in utilizing mass spectrometry alongside high-content imaging.

In 2018, he started his Ph.D. project at the Human Genetics Department of the LUMC and the Target Discovery Institute at the University of Oxford. Combining transcriptomics, proteomics and spatial metabolomics, he set out to capture the underlying impaired cellular aspects of severe, yet, untreatable age-associated muscle diseases. During his time in Oxford, he identified a novel role for USP18 during muscle cell differentiation, independent of USP18 its role in a type 1 interferon immune response. Back at the LUMC, he started creating 3D muscle bundle organoids using human muscle induced pluripotent stem cells (miPSCs). Differentiating these miPSCs into mature muscle fibers, allowed for physiological assessment of the 3D muscle bundles and further validation of promising targets in age-associated muscle wasting.

In November 2023, he joined the Islet group of prof. Eelco de Koning and dr. Fran├žoise Carlotti as a postdoc. His focus will be on developing new endocrine organoids by refining and optimizing existing differentiation protocols. Ultimately, his work aims to contribute to the development of innovative therapies for currently untreatable diseases.

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