This programme encompasses basic, clinical (both diagnostic and therapeutic) and genetic research in the field of coronary atherosclerosis, in particular lipid metabolism, vascular biology, molecular plaque imaging, and novel therapeutic interventions. To this purpose, the collaboration in the working group Leiden Vascular Medicine (LVM) and Center for Medical Systems Biology (SMSB) aims to apply innovative multidisciplinary genomics and bioinformatics to improve diagnosis, therapy and prevention of common and rare diseases.