The endothelial compartment as disease modifier in bleeding disorders

This research is part of the project “SYMPHONY: Orchestrating personalized treatment for patients with bleeding disorders”. This part of the project (WP12) focuses on the cellular mechanisms behind interindividual variation in bleeding phenotypes between patients with bleeding disorders. The hypothesis of this study is that genetic variations in secretory pathway components of platelets and endothelial cells are causative for interindividual variation in bleeding phenotype. This is a collaboration between clinical and fundamental groups at LUMC and ErasmusMC (Dr. Ruben Bierings).