Natasha Appelman-Dijkstra

Current research projects:

Brief summary of research over the last five years
Natural history and Mechanisms of Rare Bone and Mineral Diseases:
1. Clinical, biochemical, imaging, and genetic studies on rare bone diseases. Externally funded
studies include long-term skeletal and extra-skeletal effects of sclerostin deficiency (Van
Buchem disease, SOST gene); long-term effects of mutations of SQSTM1 gene in familial
Paget’s disease; management of Fibrous Dysplasia/McCune Albright (FD/MAS). Principal
investigator of the EU registry for rare bone and mineral conditions, with the acronym
EuRR-Bone (www.eurr-bone.com), funded by the European Union’s 3rd Health Program,
and lead of the working group for FD/MAS in EuRR-Bone.
Part of the project management team of EuRRECa, the European Registries for Rare Endocrine Conditions (www. eurreb.eu)
2023 PI for the DeFiD study : a novel placebo controlled trial in Denosumab and FDMAS for pain.

2. Patient empowerment/patient related outcomes
– Studies on Disease coping, Quality of life, Illness Perceptions and Pain in rare bone and
mineral conditions
– Value Based Health Care project on osteoporosis
– Development of a Dutch disease specific questionnaire for primary hyperparathyroidism

3. Novel approaches in Osteoporosis:
– Impact Microindentation Technique(IMT)
– Treatment approaches in osteoporosis: AfterDmab study, zoledronic acid after hip fractures (lead dr A.G.Vlug), sarcopenia (lead dr A.G.VLug), National Romozosumab cohort study

Specific areas group members
– Bone circadian rhythm (project lead dr. E.M.Winter)
– Pamidronate for Pain in SCCH (the PAPS trial) (project lead dr E.M.Winter)
– Bone Marrow Adiposity and longterm osteoporosis outcomes (project lead dr A.G. Vlug)
– Bone Health after bariatric surgery : the ActiViD trial (project lead dr M.A.Lips)

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Current PhD students:
Maartje Meijer, Fibrous Dysplasia
Erwin Gorter, Fracture Healing
Manuela Schob, Impact microindenation
Stijn van der Meeren-Genders, Craniofacial Fibrous Dysplasia
Wouter van der Brugge, Imaging of metabolic bone diseases
Ana Priego, Registries in rare bone and endocrine diseases
Anne Leerling, SternoCosto Claviculaire Hyperostose
Mariya Cherenko

Additional team members:
Dr. Abbey Schepers
Dr. Michiel vd Sande
Prof. R. Van Merkesteijn

External advisors
Nathalie Bravenboer
Socrates Papapoulos