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Marlous Rotman, MD

Fibrous dysplasia is a rare bone disease in which a post-zygotic mutation of the GNAS-gene causes a wide variation of clinical phenotypes, ranging from mild monostotic disease to severe polyostotic disease and even endocrinological involvement (McCune-Albright Syndrome).

I started as a PhD student in fibrous dysplasia at the Center for Bone Quality in January 2017. My research focuses on the natural history and clinical manifestations of the various forms of fibrous dysplasia, as well as on structural improvement of care for fibrous dysplasia patients. Up until now, all of our research on this disease has been based on retrospective data. One of my current projects is to establish a prospective study in our patient cohort, to ensure our database can continue to expand. Also, I am focusing on the craniofacial form of fibrous dysplasia, aiming to fully map the clinical manifestations, treatment and outcome of treatment of this disease.