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Maaike Schilperoort, MSc

Brown adipose tissue (BAT) importantly contributes to energy expenditure by burning nutrients for thermogenesis. Therefore, interventions that aim at increasing BAT activity can be used to improve metabolic health. My research conducted at the Leiden University Medical Center and the University of Warwick has led to the identification of novel targets to increase brown fat activity, i.e. AMP-activated protein kinase (Trends Mol Med, 2015) and the G protein-coupled receptor 120 (EMBO Mol Med, 2018). Currently, my research aims at elucidating how the biological clock affects BAT activity and metabolic health. I subject mice to various interventions to disrupt their circadian rhythm (i.e. by blunting rhythm in glucocorticoids or by exposing mice to shifts in light-dark cycles), and examine the effect on BAT activity and metabolism. Additionally, I subject APOE*3-Leiden.CETP mice, a humanized mouse model of atherosclerosis, to these same interventions to study effects of rhythm disturbances on atherosclerosis development.

Awards

2019 (October):
Award for best oral presentation at the Joint meeting of the Hellenic Society for the Study of Bone Metabolism (HSSBM) and the Dutch Society for Calcium and Bone Metabolism (NVCB), Athens, Greece.
2019 (February):
NVE prize for best translational abstract at the Dutch Endocrine Meeting, Noordwijkerhout, the Netherlands.
2018 (November):
Prize for best poster presentation at the Rembrandt Symposium on Cardiovascular Science, Noordwijkerhout, the Netherlands.
2018 (September):
Young Investigator Award for best oral presentation at the European Lipoprotein Club Meeting, Tutzing, Germany.
2018 (April):
Young Investigator Award for best oral presentation at the Annual Scandinavian Atherosclerosis Conference, Humlebaek, Denmark.
2016 (June):
Heart of Biomedical Sciences prize for best MSc research proposal.
2016 (April):
Young Investigator Award for best poster presentation at the Annual Scandinavian Atherosclerosis Conference, Humlebaek, Denmark.
2015 (June):
Prof. Dr. E.L. Noach prize for best BSc thesis.
2015 (April):
‘Leidse Alumnivereniging Geneeskunde’ prize for best (bio)medical BSc/MSc thesis.
2015 (April):
Young Investigator Award for best poster presentation at the Annual Scandinavian Atherosclerosis Conference, Humlebaek, Denmark.

 

Publications
1. Schilperoort M, Bravenboer N, Lim J, Mletzko K, Busse B, et al. Circadian disruption by shifting the light-dark cycle negatively affects bone health in mice. FASEB J 2019, in press.
2. Schilperoort M, van den Berg R, Bosmans LA, van Os BW, Dollé MET, et al. Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice. J Pineal Res 2019: e12614.
3. Schilperoort M, van den Berg R, Dollé MET, van Oostrom CTM, Wagner K, et al. Time-restricted feeding improves adaptation to chronically alternating light-dark cycles. Sci Rep 2019; 9(1): 7874.
4. Spaanderman DCE, Nixon M, Buurstede JC, Sips HC, Schilperoort M, et al. Androgens modulate glucocorticoid receptor activity in adipose tissue and liver. J Endocrinol 2018; 240(1): 51-63.
5. Schilperoort M, van Dam AD, Hoeke G, Shabalina IG, Okolo A, et al. The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat. EMBO Mol Med 2018; 10(3): e8047.
6. Albrecht T & Schilperoort M, Zhang S, Braun JD, Qiu J, et al. Carnosine Attenuates the Development of both Type 2 Diabetes and Diabetic Nephropathy in BTBR ob/ob Mice. Sci Rep 2017; 7: 44492.
7. Schilperoort M, Hoeke G, Kooijman S, Rensen PCN. Relevance of lipid metabolism for brown fat visualization and quantification. Curr Opin Lipidol 2016; 27(3): 242-8. [review]
8. van Dam AD, Kooijman S, Schilperoort M, Rensen PCN, Boon MR. Regulation of brown fat by AMP-activates protein kinase. Trends Mol Med 2015; 21(9): 571-9. [review]

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