hart_vol

Lisa Koorneef, MSc

Obesity and mood disorders (e.g. depression and anxiety) are highly prevalent in modern society and have been suggested to affect each other. Both states are linked to altered (re)activity of the stress hypothalamus-pituitary-adrenal (HPA-) axis and its end product cortisol. I propose that the reciprocal relationships between mood/obesity and the HPA axis result in a disease triangle in which one disease triggers the other via disturbed HPA-axis functionality. PhD objectives are to characterize interactions between the HPA-axis, obesity and brain mood circuits, and to thereby identify intervention options for metabolic and psychiatric disease.