Juliette de Klerk

The prevalence of Type 2 diabetes (T2D) is rapidly increasing affecting numerous people worldwide. A major complication of T2D can be nephropathy. This is when diabetes can cause damage to your kidneys over a long period of time, making it harder to clear extra fluid and waste from your body. Diabetic kidney disease (DKD) develops in about 40% of patients who have diabetes. Increasing evidence shows that DKD is regulated not only by many classical signaling pathways but also by circulating non-coding RNA (ncRNAs). The role and mechanisms of ncRNAs, including microRNAs and long non-coding RNAs, in DKD remains unknown and this is the topic of my PhD research.