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Françoise Carlotti, PhD

Françoise Carlotti (1978) is Assistant Professor in the group of Prof. Eelco de Koning since 2010.

After a M.Sc in Cellular and Molecular Biology obtained with highest honors from the University of Nice-Sophia Antipolis (Nice, France) in 2000, she received a PhD fellowship from the French Ministry of Education and Research and started her PhD in the department INSERM 491 headed by Prof. François Cuzin. In 2002, she obtained a 1-year Eurogendis fellowship (Marie Curie training program) and joined the group of Prof. Rob Hoeben at the LUMC. She completed her PhD (cum laude) from the University of Nice-Sophia Antipolis early 2004. In 2005 she joined the group of Dr Hans van Dam (LUMC) supported by a Marie Curie RTN fellowship. In 2006 she was appointed as a Staff scientist in the Virus and Stem cell Biology lab of Prof Hoeben. During that period she acquired expertise in human adult stem cell and islet cell biology.

In 2010, she joined the Islet Research group headed by Prof. Eelco de Koning (LUMC) as Assistant Professor. Since then, she co-manages the research team. Fundamental and translational research is being performed on primary human cells and animal models to investigate beta-cell mass adaptation and pancreatic cell plasticity, and to identify a renewable source of insulin-producing cells with a focus on future beta-cell replacement therapy.
She was workpackage leader in the DCTI (Diabetes Cell Therapy Initiative 2010-2015) consortium focused on novel beta-cell replacement therapy in patients.

As PI, she obtained research funding from JDRF, the Dutch Diabetes Research Foundation, and the Dutch Kidney Foundation. Her research interest focuses on exploring the plasticity of human pancreatic cells. Understanding the mechanisms that govern these identity changes may allow the development of novel preventive and regenerative therapeutic strategies for diabetes.