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Borja Martinez-Tellez, PhD

Role of Exercise in the cardiometabolic diseases

Exercise is an excellent therapeutic intervention for obesity, type 2 diabetes, cardiovascular disease, certain types of cancer and many other ailments. The mechanisms that may mediate these effects are not fully understood for some of these pathologies. Based on that, my main research is focused on unraveling the effect of exercise on brown adipose tissue activation, gut microbiota alteration, and lipid signaling that could explain the beneficial cardiometabolic effects of exercise in humans. In addition to that, I am using preclinical models to confirm the possible mechanism about the connection that might exist between exercise capacity, muscle function and certain bacterial species in the faces from humans. This idea has been founded by Fundación Alfonso Martin Escudero, and Gratama-Foundation and Leiden University Fonds 2020. Moreover, together with the radiology department from the LUMC, are developing a new MRI protocol for determination of the human thermogenic responses to certain stimulus.

Nowadays, it is very important for scientists to disseminate our science but we don’t know how to do that. In order to perform disseminations activities, I have co-created a platform called The Voice of Science, which main aim is to help scientists to disseminate their science via Visual Abstracts (www.thevoiceofscience.net)

Publications

Ortiz-Alvarez L, Xu H, Martinez-Tellez B. Influence of Exercise on the Human Gut Microbiota of Healthy Adults. A Systematic Review. Clinical and Translational Gastroenterology 2020.

Schönke M*, Martinez-Tellez B*, Rensen PCN. Role of the endocannabinoid system in the regulation of the skeletal muscle response to exercise. Current Opinion in Pharmacology 2020. *Equally contributed

Martinez-Tellez B, Adelantado-Renau M, Acosta FM, Sanchez Delgado G, Martinez-Nicolas A, Llamas-Elvira JM, Boon MR, Martinez-Vizcaino V, Ruiz JR. The mediator role of Brown adipose tissue and skeletal muscle in the thermoregulatory system of young adults. Obesity. 2019

Martinez-Tellez B, Sanchez-Delgado G, Amaro-Gahete FJ, Acosta FM, Ruiz JR. Relationships between cardiorespiratory fitness/muscular strength and 18F-fluorodeoxyglucose uptake in brown adipose tissue after exposure to cold in young, sedentary adults. Sci Rep. 2019

Martinez-Tellez B, Sanchez Delgado G, Alcantara JMA, Acosta FM, Amaro-Gahete FJ, Osuna-Prieto FJ, Perez-Bey A, Jimenez-Pavon D, Llamas-Elvira JM, Gil A, Aguilera CM, Rensen PCN, Ruiz JR. Evidence of metabolically active interscapular brown adipose tissue depots in adults. Exp Physiology. 2018.