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Borja Martinez-Tellez, PhD

Role of Exercise in the activation of brown adipose tissue
Exercise is an excellent therapeutic intervention for obesity, type 2 diabetes, cardiovascular disease, certain types of cancer and many other ailments. The mechanisms that may mediate these effects are not fully understood for some of these pathologies. The energy expenditure capacity of brown adipose tissue (BAT) makes it an attractive target as a therapy against obesity and type 2 diabetes. Sympathetic nervous system (SNS), through adrenergic signalling, is the classical regulator of BAT; however, recent findings have shown a pool of novel BAT activators that sidestep the need for stimulating the SNS. Of interest is that both SNS and non-SNS BAT activators are sensitive to exercise, which opens new horizons to study the potential effect exercise-based therapeutic interventions. I am working in a randomized controlled trial (ACTIvating Brown Adipose Tissue through Exercise, the ACTIBATE study), whose overall aim is to determine the effect of a 6-month exercise intervention on BAT activity and mass measured by 18F-FDG PET/CT (primary outcome) as well as on resting energy expenditure, meal induced thermogenesis, cold induced thermogenesis, body temperature regulation, body composition and cardiovascular disease risk factors (secondary outcomes) in 150 young adults (PMID: 26546068).

See my profile research gate.

Publications
Martinez-Tellez B, Adelantado-Renau M, Acosta FM, Sanchez Delgado G, Martinez-Nicolas A, Llamas-Elvira JM, Boon MR, Martinez-Vizcaino V, Ruiz JR. The mediator role of Brown adipose tissue and skeletal muscle in the thermoregulatory system of young adults. Obesity. 2019
Martinez-Tellez B, Xu H, Sanchez-Delgado G, Acosta FM, Rensen PCN, Llamas-Elvira JM, Ruiz JR. Association of wrist and ambient temperature with cold-induced Brown adipose tissue and skeletal muscle 18F-FDG uptake in young adults. Am. J. Regu. Comp. Inte. 2018
Martinez-Tellez B, Sanchez Delgado G, Alcantara JMA, Acosta FM, Amaro-Gahete FJ, Osuna-Prieto FJ, Perez-Bey A, Jimenez-Pavon D, Llamas-Elvira JM, Gil A, Aguilera CM, Rensen PCN, Ruiz JR. Evidence of metabolically active interscapular brown adipose tissue depots in adults. Exp Physiology. 2018
Martinez-Tellez B, Nahon KJ, Sanchez-Delgado G, Abreu-Viera G, Llamas-Elvira JM, van Velden FHP, Arias-Bouda L, Rensen PCN, Boon MR, Ruiz JR. The impact of using BARCIST 1.0 criteria on quantification of BAT volume and activity in three independent cohorts of adults. Sci Report 2018
Martinez-Tellez B, Sanchez-Delgado G, Garcia-Rivero Y, Alcantara JM, Martinez-Avila WD, Muñoz-Hernandez V, Olza J, Boon MR, Rensen PCN, Llamas JM, Ruiz JR. A new personalised cooling protocol to activate brown adipose tissue in young adults. Front Physiol 2017