Borja Martinez-Tellez, MSc

Role of Exercise in the activation of brown adipose tissue
Exercise is an excellent therapeutic intervention for obesity, type 2 diabetes, cardiovascular disease, certain types of cancer and many other ailments. The mechanisms that may mediate these effects are not fully understood for some of these pathologies. The energy expenditure capacity of brown adipose tissue (BAT) makes it an attractive target as a therapy against obesity and type 2 diabetes. Sympathetic nervous system (SNS), through adrenergic signalling, is the classical regulator of BAT; however, recent findings have shown a pool of novel BAT activators that sidestep the need for stimulating the SNS. Of interest is that both SNS and non-SNS BAT activators are sensitive to exercise, which opens new horizons to study the potential effect exercise-based therapeutic interventions. I am working in a randomized controlled trial (ACTIvating Brown Adipose Tissue through Exercise, the ACTIBATE study), whose overall aim is to determine the effect of a 6-month exercise intervention on BAT activity and mass measured by 18F-FDG PET/CT (primary outcome) as well as on resting energy expenditure, meal induced thermogenesis, cold induced thermogenesis, body temperature regulation, body composition and cardiovascular disease risk factors (secondary outcomes) in 150 young adults (PMID: 26546068). I am a visiting PhD student in the LUMC, and I am involved in human BAT studies at the department.

See my profile research gate.

1. Sanchez-Delgado G, Martinez-Tellez B, Olza J, Aguilera CM, Labayen I, Ortega FB, Chillon P, Fernandez-Reguera C, Alcantara JM, Martinez-Avila WD, Muñoz-Hernandez V, Acosta FM, Prados-Ruiz J, Amaro-Gahete FJ, Hidalgo-Garcia L, Rodriguez L, Ruiz YA, Ramirez-Navarro A, Muros-de Fuentes MA, García-Rivero Y, Sanchez-Sanchez R, de Dios Beas Jimenez J, de Teresa C, Navarrete S, Lozano R, Brea-Gomez E, Rubio-Lopez J, Ruiz MR, Cano-Nieto A, Llamas-Elvira JM, Jimenez Rios JA, Gil A, Ruiz JR. Activating brown adipose tissue through exercise (ACTIBATE) in young adults: Rationale, design and methodology. Contemp Clin Trials. 2015 Nov;45(Pt B):416-25.
2. Sanchez-Delgado G, Martinez-Tellez B, Olza J, Aguilera CM, Gil Á, Ruiz JR. Role of Exercise in the Activation of Brown Adipose Tissue. Ann Nutr Metab. 2015;67(1):21-32.
3. Ruiz JR, Martinez-Tellez B, Sanchez-Delgado G, Aguilera CM, Gil A. Regulation of energy balance by brown adipose tissue: at least three potential roles for physical activity. Br J Sports Med. 2015 Aug;49(15):972-3.