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Liesbeth Winter

Fascinated by (patho)physiology and endocrinopathy during High School (magna cum laude), Medicine (cum laude) and Medical Doctor’s training (2004, magna cum laude), Dr. E.M. (Liesbeth) Winter aimed to become a translational clinician scientist as internist-endocrinologist. To get trained in basic science, she performed her PhD in Embryology (2009, cum laude), followed by clinical training as internist-endocrinologist (2009-2017) in Leiden and specialist Registrar in London (2014). In 2017 she started as staff-member (clinician scientist) with a tenure track position at the Dept. of Endocrinology, and since only then started her career as specialist in bone diseases. She mainly focuses on complex osteoporosis, (rare) metabolic bone diseases and calcium/phosphate disturbances.

As PI Dr. Winter conducts a translational research program, investigating bone rhythmicity and glucocorticoid effects on bone. She recently described that disturbance in circadian rhythm is detrimental for bone health (FASEB J, 2019) and that a flattened glucocorticoid rhythm in itself is detrimental to bone (Aging Cell, 2021). She received various grants for this research line (Elise Mathilde Fund in 2017, Preasidium Libertatis Grant in 2020 -grant for the ‘most talented young researcher of Leiden University’-, Zaaijer Fund for protected research time in 2021). The research intertwines metabolic research, glucocorticoid signalling, bone diseases and is strongly acquainted to the European Reference Network and Referral Care functions of the LUMC.

She is also PI in translational research on the rare metabolic bone disease sternocostoclavicular hyperostosis (SCCH), for which she received a grant from the Dutch Arthritis Foundation to perform a randomized clinical trial on pamidronate treatment (PAmidronate for Pain in SCCH, PAPS trial) and to study the use of NaF Pet as diagnostic and prognostic tool. She performs research on impact microindentation (international expert trainer in impact microindentation) in complex osteoporosis and metabolic bone diseases, and she is involved in various other clinical research projects including bone diseases after solid organ transplantation, complex osteoporosis and parathyroid disorders.

She has received multiple grants and prizes, and she was elected European Calcified Tissue Society (ECTS) -academy member in 2018. She is nationally and internationally recognized as expert in the field which is reflected by her various invitations to speak at international congresses. She serves in various committees including the Research Committee of the Department of Internal Medicine in the LUMC, the American Society for Bone and Mineral Research (ASBMR) Early Stage Investigator (ESI) committee, the International Federation of Muskuloskeletal Research Societies (IFMRS) Future Global Leaders Committee and multiple ECTS committees. Since 2021 she serves as expert member of the parathyroid (PARAT) working group from the European Society of Endocrinology (ESE), and on the editorial board of Endocrine Connections.

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