Françoise Carlotti, PhD

Françoise Carlotti (1978) is Associate Professor and Head of the Islet Research lab.

After a M.Sc in Cellular and Molecular Biology obtained with highest honors (2000), she received a PhD fellowship from the French Ministry of Education and Research and started her PhD in the department INSERM headed by Prof. François Cuzin. In 2002, she obtained a 1-year Eurogendis fellowship (Marie Curie training program) and joined the group of Prof. Rob Hoeben at the LUMC. She completed her PhD (cum laude) from the University of Nice-Sophia Antipolis early 2004. In 2005 she joined the group of Dr Hans van Dam (LUMC) supported by a Marie Curie RTN fellowship. In 2006 she was appointed as a Staff Scientist in the Virus and Stem cell Biology lab of Prof Hoeben. During that period she acquired expertise in human adult stem cell and islet cell biology.

In 2010, she joined the Islet lab of Prof. Eelco de Koning as Assistant Professor and head of the basic research team, and became Associate Professor in 2020. Fundamental and pre-clinical research is being performed on type 1 and type 2 diabetes, with a focus on primary human pancreatic cells. Among the topics of interest are investigating mechanisms underlying beta-cell adaptation, beta-cell plasticity and alterations in beta-cell identity associated with a loss of function. Furthermore, the Islet lab has a major interest in beta-cell replacement therapy strategies. Building on an active clinical islet transplantation program, we are interested in exploring alternative sources of insulin-producing cells from potential adult progenitor cells and pluripotent stem cells.

As PI, Françoise Carlotti obtained research funding from JDRF (2014 and 2017), the Dutch Diabetes Research Foundation (2015, 2019), the Dutch Kidney Foundation (2016), the DON foundation (2017, 2019), the European Foundation for the Study of Diabetes (2018), and TKI/Health Holland (2019).

She was workpackage leader in the Dutch consortium DCTI (Diabetes Cell Therapy Initiative 2010-2015). She is a PI in the Dutch initiative RegMedXB, as well as in the H2020 European consortia ISLET and ESPACE.

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